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Observation on Therapeutic Effect of Tuhuanglian Lotion for the Treatment of Acute Radiation Dermatitis in Breast Cancer Patients

ZOU Ni-qian;LIN Yi;WANG Zhen-hui;SITU Hong-lin;The Second Clinical Medical School,Guangzhou University of Chinese Medicine;Guangxi International Zhuang Medicine Hospital;The Second Affiliated Hospital of Guangzhou University of Chinese Medicine;  
Objective To observe the clinical effects of Tuhuanglian lotion wet compress on acute radiation dermatitis of breast cancer patients. Methods By using the method of clinical randomized controlled study,70cases of breast cancer patients meeting the inclusion criteria and planning to perform postoperative radiotherapy were randomly divided into two groups. The trial group was assigned 36 cases and the control group was assigned 34cases. The control group was given routine nursing and health training. On the basis of the treatment for the control group,the trial group was given wet compress of Tuhuanglian lotion on the skin of the radiation area. The RTOG grade, incidence of acute radiation dermatitis, visual analog scale(VAS) scores of skin pain and itching,erythema degree,and the incidence of adverse reactions were compared between the control group and the trial group within 3 weeks after the initiation of RT. Results Eventually,a total of 36 cases in the trial group and 31cases in the control group completed the trial. On the 14th and 21st day of radiotherapy,the RTOG grade of the trial group was lower than that of the control group,and the difference was statistically significant(P0.05). The incidence of radiation dermatitis in the trial group was lower than that of the control group,and the difference was statistically significant(P0.05). At each time points of observation,the degree of erythema in the skin of the radiation area,VAS scores of skin pain and itching of the trial group was lower than that of the control group,and the difference was statistically significant(P0.05). There were no related adverse reactions occurring in both groups. Conclusion The application of Tuhuanglian lotion during radiotherapy for breast cancer patients can reduce the incidence and the severity of acute radiation dermatitis, and relieve erythema, pain and pruritus effectively. No adverse reactions occur during the treatment.
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