Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

Comparison the Therapeutic Mechanism of Chutan Jiedu Decoction and Yiqi Chutan Decoction for the Treatment of Lung Cancer Based on Network Pharmacology

WANG Shu-mei;SZE Cho Wing;YUNG Ken Kin Lam;FU Qiang;FANG Yu-xiao;CHEUNG Lai Man;College of Traditional Chinese Medicine,Chongqing Medical University;Chongqing Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Metabolic Diseases;Department of biology,Hong Kong Baptist University;Shenzhen Research Institute of Hong Kong Baptist University;  
Objective To compare the therapeutic mechanism of Chutan Jiedu Decoction and Yiqi Chutan Decoction for the treatment of lung cancer based on network pharmacology. Methods TCMSP database was used for searching the active components of the herbs of Chutan Jiedu Decoction and Yiqi Chutan Decoction. Gene Cards database were used for obtaining the disease targets related to lung cancer. The enrichment analysis of GO-BP and KEGG pathway was performed by Cytoscape software and Funrich software. Results There were 30 and 33intersection targets of Chutan Jiedu Decoction with lung cancer and Yiqi Chutan Decoction with lung cancer respectively. The expression rates of Chutan Jiedu Decoction and Yiqi Chutan Decoction in normal lung tissue respectively were 70.42%, 69.84% respectively, and those in lung cancer tissue were 63.38%, 63.49%respectively. The main biological processes of the two prescriptions involved metabolism, signal transduction,apoptosis,immune response regulation. KEGG pathway enrichment analysis indicated that the two prescriptions had the highest expression rate in TRAIL signaling pathway. Conclusion(1) The target proteins of the two prescriptions have affinity in normal lung tissue and tumor tissue, indicating that the prescriptions do not specifically act on cancer cells.(2)The target proteins of the two prescriptions express affinity with lung and lung related viscera, showing the systematic and holistic concept of traditional Chinese medicine treatment.(3) The target proteins have affinity expression with spleen related viscera, indicating that the two prescriptions are indicated for spleen deficiency syndrome and will provide guidance for the treatment of lung cancer with the therapy of cultivating earth(spleen)to generate metal(lung).(4)Both of the two prescriptions have the highest expression level in the sptan1 gene and TRAIL signaling pathway,which will provide new ideas for targeted drug research.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved