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Study on the whitening and sunscreen effects of proanthocyanidins from Acacia mearnsii bark

LIU Gongjun;ZHOU Meng;YE Fengxia;XIONG Jia;JIANG Ping;LI Xun;ZHANG Yu;WANG Fei;Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources,College of Chemical Engineering,Nanjing Forestry University,Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals;  
Proanthocyanidins are a class of bioactive flavonoids with good physiological and pharmacological effects and thus have great potential applications in the field of health products,cosmetics and pharmaceuticals. In this study,a sunscreen was prepared by using the proanthocyanidins extracted from Acacia mearnsii bark,which is a traditional feedstock for the production of tanning extract,and the whitening and sunscreen effects of the proanthocyanidins were discussed. The results indicated that the IC50 value of tyrosinase inhibition by the proanthocyanidins was 0. 44 g / L,illustrating that the proanthocyanidins from Acacia mearnsii bark could significantly inhibit the production of melanin and had whitening effect. Meanwhile,study on the enzymatic kinetics of tyrosinase inhibition by proanthocyanidin showed that the inhibition was the competitive type. In addition,the tests on the absorption in ultraviolet B( UVB) region(280-320 nm) and the anti-ultraviolet of mice showed that the sunscreen containing 3%( w / w) proanthocyanidins had moderate protective effect to the radiation of ultraviolet,and could be well used to protect the skin from moderate sunlight. The sunscreen effect was almost the same as the commercially available sunscreen. Therefore,the proanthocyanidins from Acacia mearnsii bark are the traditional forest products that could be applied to active ingredients of whitening sunscreen,and helped to expand the application of the bioactive substances coming from forests.
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