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Effects of Valeriana officinalis L.var latifolia Miq. on Blood-lipid Metabolism in Rabbits with Hyperlipidemia

Hu Changxing; Zhang Daobin; Li Hua; Wang Chunhui; Tao Yueyu; Yang Guiyuan; Li Gengshan (Department of Cardiology, 414 Naval Hospital, Nanjing 210015)  
Objective: To observe the effects of Valeriana officinalis L. var latofolia Miq. (VOL) oil on blood-lipid metabolism in rabbits with hyperlipidewha. Methods: Twenty-four healthy male rahbits (weighing 2 .0 - 2.5 kg ) were immunologically injured and fed with the hypercholesterol diet for 45 days. The rabbits were randornly divided into four groups (n = 6 in each ): (1) hyperlipidemia con- trol group(A); (2) low-dose VoL group (B ); (3 ) high-dose VOL group (C) and (4) Simvastatin group (D). The levels of TC, TG, LDL-C, HDL-C, MDA and SOD were determined respectively hefore the experiment on the 45th, 75th and lo5th day. Results: (1) VOL oil reduced the levels of TC, TG and LDL-C in group C and D and elevated the level of HDL-C signilicantly. There were significant differences between group C, group D and group A (P 0.05 ) , and there was no significant difference between group C and group D(P 0 .05). (2) Both VOL oil and Simvastatin reduced the level of MDA and ele- vated the level of SOD (as compared with group A at the same time, P 0 .05). Conclusion: The re- sults indicate that VOL oil has remarkably lipid-regulating and anti-lipid peroxidation effects.
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