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The significance of serum thymidine kinase 1 on assistant diagnosis and evaluation of chemotherapy effect on breast cancer patients operated

YUAN Zi-yu,LIU Xiao-an,LING Li-jun,ZHAO Yi,WANG Shui(Department of Breast Surgery,the First Affiliated Hospital of NJMU,Nanjing 210029,China)  
Objective:To evaluate the serum thymidine kinase 1(TK1)as a tumor marker for early tumor detection and monitoring chemotherapy effect on breast cancer patients operated.Methods:A sensitive chemiluminescence dot-blot assay was used to detect serum TK1 level in breast cancer patients(48 cases),including post-treated breast cancer patients(14 cases).Results:Forty eight cases had the pathological stage data.In order to exam the effect of chemotherapy,14 cases were chose to be followed-up for 1~3 months.Serous TK1 level in 10 of 14 cases was decreased to the level of healthy volunteers;four in 14 cases had a increased serous TK1 level,and one of them progressed bone metastasis one year later.Conclusion:Serous TK1 level has a correlation to the proliferation of breast cancer cell.Serum TK1 is a favorable and helpful marker for monitoring the response of chemotherapy.
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