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Protective Effects of Sedum Lineare Thunb on Experimental Acute Hepatic Injury in Mice

ZHOU Qing,LIU Jian-xin,ZHOU Li,XIONG Xiao-qin,ZHAO Hai-yan(Gannan Medical College,Ganzhou 341000,China)  
Objective:To observe the protective effects of solution isolated from sedum lineare thunb on experimental acute hepatic liver injury in mice.Methods:To observe the contents of total bilirubin and alanine aminotransferase(ALT)in serum,the contents of malondialdehyde(MDA),activity of superoxide dismutase(SOD),level of nitrogen monoxide in serum and liver tissue,hepato-pathohistologic changes by CCl_4,α-naphthalin fluorescein isothiocyanate(ANIT) inducing acute liver injury and icterus respectively in mice by po,the effects of sedum lineare thunb on the biochemical changes were analysed.Results:The results showed the extract of sedum lineare thunb could significantly decrease the contents of ALT in serum and the contents of MDA in serum and liver tissue respectively in CCl_4 toxico-mice(P0.01),increase the activity of SOD and the level of NO in serum and liver tissue respectively(P0.01,P0.001);the extract could markedly reduce the contents of TBil in serum in ANIT toxico-mice(P0.001).The result of hepato-pathohistologic examination showed the extract effectively decreased degeneration and necrosis of liver cells.Conclusion:The extract of sedum lineare thunb has the protective effects on acute liver injury in mice induced by CCl_4 and ANIT.The mechanism is likely related to its ameliorating microcirculation and anti-lipid peroxidation.
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