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STUDY ON THE ANTIVIRAL ACTIVITIES OF CONDENSED TANNIN OF ARTEMISIA ANNUA L.

ZHANG Jun-feng,TAN Jian,PU Qiang,LIU Ying-hua,LIU Yue-xue,HE Kai-ze * (Chengdu Institute of Biology,Chinese Academy of Sciences,Chengdu 610041,China)  
Inhibitory effects of condensed tannin of Artemisia annua L.(CTA) on herpes simplex virus type 2(HSV-2) and HBeAg secretion in cultured HepG2.2.1.5 cell line were investigated.When the anti-HSV-2 activity of CTA was tested with acyclovir(ACV) as contrast drug,CC 50 of CTA and ACV were 6.84 mg/mL and 3.69 mg/mL,IC 50 were 0.162 mg/mL and 0.138 mg/mL respectively.The results showed CTA was as effective as the clinical drug-ACV.To study the anti-hepatitis B virus activity of CTA,the cytotoxicity to 2.2.1.5 cell line and inhibition of HBeAg secretion were tested.The results showed that CTA had slight cytotoxicity at 2.5 mg/mL and can distinctly inhibit the secretion of HBeAg in HepG2.2.1.5 cell line.All the results indicated that CTA maybe have a high selectivity index against HSV and HBV.
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