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《Chinese Journal of New Drugs and Clinical Remedies》 2009-07
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Clinical study on combined treatment of thalamic pain using duloxetine and mecobalamin

FU Jian-liang,YAO Ji-guo,XIANG Jing-yan,JIANG Qing-qing(Department of Neurology,Shanghai Jiaotong University Affiliated No.6 Hospital,SHANGHAI 200233,China)  
AIM To evaluate the safety and efficacy of different therapeutic effect of thalamic pain after stroke.METHODS Sixty-five patients with thalamic pain were randomly divided into two group:33 patients received the combined treatment with duloxetine capsule 40 mg·d-1 and mecobalamin tablets 1 500 μg·d-1(combined-treatment group),and 32 patients of controls received duloxetine capsule 40 mg·d-1(control group).RESULTS There was significant difference in visual analogue scale(VAS) of the combined-treatment group before and after the treatment(7.5 ± s 1.2 vs 4.8 ± 0.9,P 0.01) with no difference in the control group(7.4 ± 1.1 vs 6.8 ± 1.3,P 0.05).There was significant difference in VAS and clinical cure rate(67% vs 34%) between the two group after the treatment(P 0.01).The adverse reactions rate of the combined-treatment group and the control group was 12% and 12%,respectively(P 0.05).CONCLUSION The curative effect of combined treatment with duloxetine and mecobalamin is better than that of duloxetine single used.
【CateGory Index】: R743.3
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 GUO Xiao-feng ZHAO Jing-ping CHEN Jin-dong(Mental Health Institute,the 2nd Xiangya Hospital of Centre South University,Changsha HU-NAN 410011,China);Duloxetine:a novel antidepressant[J];Chinese Journal of New Drugs and Clinical Remedies;2006-07
2 GAO Cheng-ge~1 WANG Gang~2 XU Xiu-feng~3 XIE Shi-ping~4 TAN Qing-rong~5 DU Bo~6 CHENG Neng-neng~7 WANG Wei~1 CHEN Ce~1 FU Wei~1 YANG Xiao-bo~1 KANG Wan-hu~1 LI Qiang~1 MA Xian-cang~1 (1.The First Affiliated Hospital of Xi-an Jiaotong University,Xi-an SHAANXI 710061,China; 2.Beijing Anding Hospital Attached to the Capital Medical University,BEIJING 100088,China; 3.The First Affiliated Hospital of Kunming Medical College Kunming YUNNAN 650032,China; 4.Nanjing Brain Hospital,Nanjing JIANGSU 210294,China; 5.The Xijing Hospital Attached to the Fourth Military Medical University of PLA,Xi-an SHAANXI 710032,China; 6.Mental Health Center of Hebei Province,Baoding HEBEI 071000,China; 7.The Medicine College of Fudan University,SHANGHAI 200032,China);Multi-center,randomized,and double-blind controlled clinical trial of duloxetine enteric capsule in treatment of depression[J];Chinese Journal of New Drugs and Clinical Remedies;2008-07
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Qian Mincai, Lin Min, Shen Xinhua, Zhong Hua, Zhu Yiping, Yang Jianhong. The third Municipal Hospital of Huzhou, Zhejiang Province, Huzhou 313000;Comparative study of duloxetine with venlafaxine in the treatment of first episode depression[J];Shanghai Archives of Psychiatry;2008-05
2 Xu Lqin.The Third People's Hospital of Jiangmen,Guangdong Province,Jiangmen 529000;A comparative study of duloxetine versus escitalopram in female patients with depressive disorder[J];Shanghai Archives of Psychiatry;2009-03
3 WANG Xiang-li.Mental Health Center of Linyi Shandong Province,Linyi 276005,China;Comparison study of duloxetine and paroxetine in the treatment of depression with generalized anxiety disorder[J];Journal of Clinical Psychiatry;2009-04
4 Liu Shoumei,the Mental Health Center of Linyi City,Shandong Province 276005;A Contrast Study of Duloxetine and Fuloxetine in the Treatment of Post-schizophrenia Depression[J];Journal of Military Surgeon in Southwest China;2009-05
5 DAI Min.Mental Health Center of Yunnan Province,Kunming 650000,China;A Controlled Study in Treatment of Depression with Duloxetine and Fluoxetine[J];Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease;2010-07
6 MAO Qing-xiang~(1,2) YANG Tian-de~1 (1.Department of A nesthesiology,Xingqiao Hospital,the Third Military Medical University of PLA,CHONGQING 400037,China;2.Department of Anesthesiology,Daping Hospital,Institute of Surgery,the Third Military Medical University of PLA,CHONGQING 400042,China);Advances in study for efficacy of duloxetine in pain treatment[J];Chinese Journal of New Drugs and Clinical Remedies;2008-04
7 GAO Cheng-ge~1 WANG Gang~2 XU Xiu-feng~3 XIE Shi-ping~4 TAN Qing-rong~5 DU Bo~6 CHENG Neng-neng~7 WANG Wei~1 CHEN Ce~1 FU Wei~1 YANG Xiao-bo~1 KANG Wan-hu~1 LI Qiang~1 MA Xian-cang~1 (1.The First Affiliated Hospital of Xi-an Jiaotong University,Xi-an SHAANXI 710061,China; 2.Beijing Anding Hospital Attached to the Capital Medical University,BEIJING 100088,China; 3.The First Affiliated Hospital of Kunming Medical College Kunming YUNNAN 650032,China; 4.Nanjing Brain Hospital,Nanjing JIANGSU 210294,China; 5.The Xijing Hospital Attached to the Fourth Military Medical University of PLA,Xi-an SHAANXI 710032,China; 6.Mental Health Center of Hebei Province,Baoding HEBEI 071000,China; 7.The Medicine College of Fudan University,SHANGHAI 200032,China);Multi-center,randomized,and double-blind controlled clinical trial of duloxetine enteric capsule in treatment of depression[J];Chinese Journal of New Drugs and Clinical Remedies;2008-07
8 ZHOU Ying-zhen,WANG Guo-hai,LIU Xiu-ying,CHEN Jian-zheng(Research & Development Center of Jiang Su Nhwa Pharma.Corparation,Xuzhou 221007,China);HPLC direct enantiomeric separation of duloxetine[J];Chinese Journal of Pharmaceutical Analysis;2009-04
9 Xiao Jian(Fujian Health College,Fuzhou,Fujian,China 350101);Improved Synthesis of Duloxetine Hydrochloride[J];China Pharmaceuticals;2009-04
10 GONG Lian-bing(The 305th Hospital of PLA,Beijing 100017,China);Evaluation on the Rational Use of Drugs for Selective Serotonin and Norepinephrine Reuptake Inhibitors(SSNRI)[J];Evaluation and Analysis of Drug-Use in Hospitals of China;2009-05
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 WEN Xin-min, MAO Qing-hua, TANG Jian, YU Xin-hong (College of Chemistry and Pharmaceutic, East China University of Science and Technology, Shanghai 200237, China);Development in the Synthesis of Duloxetine[J];Chinese Journal of Synthetic Chemistry;2004-06
2 GUO Xiao-feng ZHAO Jing-ping CHEN Jin-dong(Mental Health Institute,the 2nd Xiangya Hospital of Centre South University,Changsha HU-NAN 410011,China);Duloxetine:a novel antidepressant[J];Chinese Journal of New Drugs and Clinical Remedies;2006-07
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