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Clinical study on combined treatment of thalamic pain using duloxetine and mecobalamin

FU Jian-liang,YAO Ji-guo,XIANG Jing-yan,JIANG Qing-qing(Department of Neurology,Shanghai Jiaotong University Affiliated No.6 Hospital,SHANGHAI 200233,China)  
AIM To evaluate the safety and efficacy of different therapeutic effect of thalamic pain after stroke.METHODS Sixty-five patients with thalamic pain were randomly divided into two group:33 patients received the combined treatment with duloxetine capsule 40 mg·d-1 and mecobalamin tablets 1 500 μg·d-1(combined-treatment group),and 32 patients of controls received duloxetine capsule 40 mg·d-1(control group).RESULTS There was significant difference in visual analogue scale(VAS) of the combined-treatment group before and after the treatment(7.5 ± s 1.2 vs 4.8 ± 0.9,P 0.01) with no difference in the control group(7.4 ± 1.1 vs 6.8 ± 1.3,P 0.05).There was significant difference in VAS and clinical cure rate(67% vs 34%) between the two group after the treatment(P 0.01).The adverse reactions rate of the combined-treatment group and the control group was 12% and 12%,respectively(P 0.05).CONCLUSION The curative effect of combined treatment with duloxetine and mecobalamin is better than that of duloxetine single used.
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