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Study on Anti-obesity Effects of Compound Citrus reticulata Combinations

LIU Wen-zhi,LU Hua-jie,YE Xiao-chuan,HUANG Jie,WANG Long-fei,LIU Yan-wen(College of Pharmacy,Hubei University of Traditional Chinese Medicine,Wuhan 430061,China)  
OBJECTIVE:To study the role of lipid-lowering and losing weight of Compound Citrus reticulata combinations(CPZHW) on the nutritional obese rats.METHODS:The nutritional obesity rat model was established and then divided into 6 groups,i.e.blank control group(constant volume normal saline),model group(constant volume normal saline),atorvastatin group(10 mg·kg-1) and CPZHW low-dose,medium-dose and high-dose groups(600、300、150 mg·kg-1).They were given drugs intragastrically once a day for 45 consecutive days.The contents of total cholesterol(TC),triglyceride(TG),high-density lipoprotein(HDL-C),low density lipoprotein(LDL-C) as well as glucose tolerance in serum were assayed.The amount of increasing weight,food intake and utilization ratio,Lee's index,body-fat ratio,The epididymal fat pad weight,perirenal fat pad weight and the quantities of fat cell in a view were observed.RESULTS:Compared with model group,the body weight,ratio of body weight-lipid,epididymis,perinephric fat-pad of CPZHW high-dose,medium-dose and low-dose groups were decreased significantly(P0.01 or P0.05),serum content of TG in rats decreased significantly(P0.01 or P0.05),HDL-C content were increased significantly(P0.01);the number of fat cells in CPZHW high-dose and medium-dose groups were increased significantly(P0.01 or P0.05),Lee's of CPZHW medium-dose group was decreased significantly(P0.01).Sugar tolerance had no significant difference in those groups(P0.05).CONCLUSION:CPZHW plays the role of lipid-lowering and losing weight on nutritional obese rats.
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