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Effects of Rutaecarpine on Cerebral Ischemia-Reperfusion in Mice and its Mechanisms

YAN Chun-lin,ZHANG Ji,GAO Yan-qing,WU Xue-zhi,WANG Shu,XUE Gui-ping(Pharmaceutical Department,Hebei North University,Zhangjiakou 075000,China)  
Objective:To observe the protective function of rutaecarpine(Rut)on learning and memory impairment induced by cerebral ischemia-reperfusion in mice and its possible mechanisms.Method:The bilateral common carotid artery occlusion for 5 min were conducted in mice,the mice in Rut-treated groups were administered with Rut(84,252,504 μg·kg-1,respectively)ip before 30 min of the operation.The other groups were administered with DMSO(0.02 mL·10 g-1).The abilities of learning and memory were examined by step-down test.The content of nitric oxide(NO) and the activities of nitric oxide syhthase(NOS) and inducible nitric oxide synthase(iNOS) were measured by UV spectrophotometry scenery.Result:Focal cerebral ischemia-reperfusion injury could induce the disorder of learning and memoryin step-down test,the latency of Rut-treated groups was significantly extended(P0.01),rutaecarpine could decrease the content of NO significantly and the activities of NOS and iNOS in mice brain.Conclusion:Rut could significantly improve the impairment of learning and memory and might decrease cerebral ischemia reperfusion injury by decreasing the activities of NOS and iNOS of mice brain.
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