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Effect of Gansu Granule on Patients with Chronic Hepatitis B

MO Qing-lian1*,WANG Zhen2(1.Pharmaceutical Department,the People's Hospital of Hainan Province,Haikou 570311,China; 2.Biotechnology Laboratory,Hainan Medical College,Haikou 571101,China)  
Objective:To investigate the effect of Gansu granule on patients with chronic hepatitis B(CHB).Method:Eighty-six subjects were randomly divided into observation group and control group(n=43 each).Pegasys were given to the control group,180 μg each time,1 time each week.Based on the pegasys treatment,Gansu granule was added to the observation group,9 g,tid,all for 24 weeks.Interlukin-21(IL-21) level,hepatitis B virus-DNA(HBV-DNA) and lung function were quantified and measured.Result:The level of HBV-DNA in both groups after the treatment were lower than those before,the observation group were more lower than that in the control group(P0.05).IL-21 level in both groups after the treatment were higher than before,the level in observation group was higher than that in the control group(P0.01).Aspartate aminotransferase(AST),alanine aminotransferase(ALT),γ-glutamete transpeptidase(GGT) and total bilirubin(Tbil) in the observation group after the treatment were lower than those in the control group(P0.05,P0.01),and albumin(Alb) of the observation group after the treatment were higher than that in the control group(P0.05).Conclusion:Gansu granule can elevate IL-21 level for the patients with CHB.Gansu granule has anti-HBV function and could protect liver function.
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