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Antibacterial and Antiinflammatory Effects of Eucalyptol

ZHANG Li-jia,XUE Yin,ZHANG Cen-rong,HU Song-hua(Department of Veterinary Medicine,College of Animal Sciences,Zhejiang University,Hangzhou 310058,China)  
To study the antibacterial and antiinflammatory effects of eucalyptol,totally 37 strains isolated from bovine with endometritis were used to determine the minimal inhibitory concentration(MIC) and minimal bactericidal concentration(MBC) by double broth dilution method.To investigate the antiinflammatory effects of eucalyptol,two inflammation models including xylene-induced ear edema and acetic acid-induced peritoneal capillary permeability addition in mice were designed respectively.The results indicated that eucalyptol had antibacterial actions on 7 kinds of isolations,the MIC and MBC were 3.9~12.4 mg/mL and 6.0~18.2 mg/mL respectively.Moreover,eucalyptol could significantly inhibit ear edema and capillary permeability increase in mice,and 400 mg/kg was considered to be the best administration dosage.In conclusion,eucalyptol had both antiinflammatory effect and antibacterial activities against bacteria isolated from dairy cows with endometritis.
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