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In-vitro Screening of Anti-tumor Active Extracts from Herb of Reineckia carnea and Its Fruits

LIU Hai1,YANG Jianqiong2,MA Huamou2,XU Xiaojun2(1.Gannan Medical College,Ganzhou 341000 Jiangxi,China;2.The First Affiliated Hospital of Gannan Medical College,Ganzhou 341000 Jiangxi,China)  
Objective To screen the anti-tumor activity of the extracts from the herb of Reineckia carnea and its fruits.Methods With human kidney clear cell adenocarcinoma 786-O cells,human colon carcinoma HT-29 cells and human pulmonary adenocarcinoma A549 cells as the tested cells,the in-vitro anti-tumor activity of ethanol extract,n-butanol extract and acetoacetate extract isolated from the herb of Reineckia carnea and its fruits was measured by methyl thiazolyl tetrazolium(MTT)colorimetry.Results Ethanol extract and n-butanol extract from the herb of Reineckia carnea,and acetoacetate extract and n-butanol extract from its fruits showed various anti-tumor activity on the tumor cells.The 50 % inhibiting concentration(IC50)of n-butanol extract from the herb of Reineckia carnea against 786-O,HT-29 and A549 cell lines was 92.78,96.04 and 63.24 mg.L-1,respectively;n-butanol extract from the fruits of Reineckia carnea had certain proliferation-inhibitory effect on 786-O,HT-29 and A549 cell lines,the IC50 being 179.03,189.67 and 329.95 mg.L-1,respectively.Conclusion n-butanol extract from the herb of Reineckia carnea is the main anti-tumor active part.
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