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Effect of Sedum lineare Thunb on adjuvant arthritis in rat and its effect of inflammatory factors

Zhou Qing;Sui Rongyan;Lian Leifan;Cao Xingling;Wu Lizhen;Huang Zhihua;Gannan Medical University;  
Objective : To investigate the therapeutic effect of Sedum lineare Thunb(SLT) on adjuvant arthritis(AA) and it's mechanisim about cytokines and inflammatory mediators.Methods: The adjuvant-induced arthritis rat animal modele was used.Primary and Secondary paw swelling of AA rats were measured.The changes of thymus or spleen index were observed.The TNF-α and IL-6 levels in serum and PGE 2 content in the joint fluid were detected.Results: Compared with model group,low SLT and high SLT both can inhibited primary and secondary paw swelling of AA rats,and downregulated the thymus and spleen index.After treatment with SLT,the levels of TNF-α and IL-6 in serum and PGE 2 contern in joint fluid were decreased obviously.Conclusion: SLT had the therapeutic effect on AA rats,the possible mechanism correlates with the regulation of immune function by reduce the inflammatory cytokines and inflammatory mediators.
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